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12 Best Enterprise Medical Software Shortlist

I've shortlisted these as the top 12 enterprise medical software:

  1. eClinicalWorks - Best for integrated healthcare management and patient engagement
  2. Oracle Cerner - Best for comprehensive data analytics and patient information security
  3. NextGen - Best for enhancing practice efficiency with a seamless interface
  4. Greenway Health - Best for revenue cycle management and billing solutions
  5. Compulink - Best for multi-specialty practices seeking a customizable platform
  6. PracticeFusion - Best for small to mid-size practices requiring a cloud-based EHR
  7. Epic - Best for large healthcare organizations prioritizing patient care coordination
  8. PrognoCIS - Best for streamlined scheduling and easy e-prescribing
  9. AdvanceMD - Best for practices desiring an all-in-one medical management solution
  10. Kareo - Best for independent practices seeking a user-friendly interface
  11. PureOHS - Best for occupational health and safety management
  12. AthenaHealth - Best for improved revenue capture and claim management

I understand how pivotal the right enterprise medical software can be. With the demands of MACRA, Meaningful Use, MIPS, and managing referrals, it's also vital to find a software vendor that truly comprehends these complexities. Enterprise medical software essentially streamlines your workflow, integrating disparate processes into one cohesive system.

The benefits are also multi-faceted - it helps in the efficient management of medical records, patient scheduling, billing, and more, thereby optimizing your practice's productivity and revenue. The main pain points this software addresses are uncoordinated processes, loss of patient data, inefficient billing, and difficulties in compliance with healthcare regulations. All these can make managing a healthcare practice a monumental task. That's why I've taken the time to compile a list of top enterprise medical software options that I believe could be the right fit for your specific needs.

What is Enterprise Medical Software?

Enterprise medical software represents a sophisticated digital toolbox designed to streamline healthcare operations, enhance patient care, and optimize administrative tasks. These robust platforms cater to a broad spectrum of users, including hospital networks, individual practices, clinicians, and healthcare professionals, enabling them to manage patient records, facilitate billing and coding, streamline appointment scheduling, and much more.

Enterprise medical software integrates various functionalities, thus providing a comprehensive solution for clinical, financial, and regulatory aspects of healthcare management. This translates to increased efficiency, improved patient outcomes, and significant time and cost savings for healthcare providers.

Enterprise Medical Software Overviews

1. eClinicalWorks - Best for integrated healthcare management and patient engagement

eClincalWorks enterprise medical software interface
Here's the screenshot of eClinicalWorks' patient portal.

eClinicalWorks offers an innovative solution designed to transform the realm of healthcare IT. By incorporating the likes of Electronic Health Records (EHR), Practice Management (PM), and Population Health (PHM), this software also serves as a comprehensive system, placing patient engagement and healthcare management in a single integrated platform.

Why I Picked eClinicalWorks:

As I evaluated the terrain of enterprise medical software, eClinicalWorks distinguished itself with its all-inclusive healthcare solution. I selected this tool due to its impressive blend of features that manage the healthcare journey from scheduling appointments to follow-up care. Moreover, it shines in the domain of integrated healthcare management, enabling medical professionals to coordinate services and care for patients with ease, substantiating its title as the best for patient engagement.

Standout features & integrations:

eClinicalWorks presents a patient portal feature that lets patients engage with their demographics, medical history records and communicate with their healthcare providers directly. Additionally, Healow TeleVisits provides remote patient care effectively with its interoperability feature that ensures seamless sharing of health records across different medical institutions.

eClinicalWorks integrates with numerous medical devices and labs, ensuring a continuous flow of data. It also boasts integration with the CommonWell Health Alliance, enhancing data sharing and interoperability with other platforms.


From $499/user/month (billed annually). This price includes base EHR features, telehealth, and patient engagement tools.


  • Offers comprehensive and integrated healthcare management
  • Excellent patient engagement via a dedicated portal
  • Strong interoperability for efficient data sharing


  • Pricing may be prohibitive for smaller practices
  • Interface may require time for new users to familiarize themselves
  • Reporting functionalities can be complex to use

2. Oracle Cerner - Best for comprehensive data analytics and patient information security

Oracle Cerner enterprise medical software interface
Here's the Oracle Cerner website screenshot.

Oracle Cerner takes healthcare technology to a new level by providing an environment that effectively analyzes and secures patient data. With its focus on robust analytics and stringent information security, Cerner also builds an impenetrable fortress around sensitive patient information.

Why I Picked Oracle Cerner:

In my exploration of the enterprise medical software landscape, Oracle Cerner captured my attention with its emphasis on data analytics and information security. Its stellar analytical capabilities, combined with secure data handling, elevated Cerner above the competition. The software's ability to provide deep, insightful analytics, while safeguarding patient information, validated my belief that it is the best tool for comprehensive data analytics and patient information security.

Standout features & integrations:

Oracle Cerner presents powerful data analytics tools that provide healthcare professionals with in-depth insights into patient health trends. The software also exhibits high standards of information security, ensuring that sensitive patient data remains uncompromised.

Cerner integrates well with a variety of mobile devices such as Smartphones (iPhones and Android phones) iPhones, iPads, desktop computers, laptops, and systems, facilitating the seamless exchange of patient health data. It also supports integration with financial systems, helping organizations handle billing and insurance claims (Medicare/Medicaid) more efficiently.


Pricing upon request.


  • Strong focus on data analytics and patient information security
  • Comprehensive suite of integrated healthcare solutions
  • Wide range of integration capabilities


  • Pricing information not readily available
  • May have a steep learning curve for new users
  • Some users report occasional software slowdowns

3. NextGen - Best for enhancing practice efficiency with a seamless interface

NextGen enterprise medical software interface
Here's NextGen's dashboard screenshot.

NextGen Healthcare brings a fresh approach to enterprise medical software by prioritizing large practices’ efficiency through an intuitive interface. By merging essential healthcare tasks into one platform, NextGen also fosters an environment that allows professionals to manage their practice effortlessly.

Why I Picked NextGen:

NextGen caught my eye with its promise to streamline workflows and elevate large practices’ efficiency. Its capacity to house key healthcare operations within a user-friendly interface is what sets it apart from the pack. With NextGen's capability to render tasks manageable and hassle-free, it also stands out as the best tool for enhancing practice efficiency with a seamless interface.

Standout features & integrations:

NextGen shines with its fully integrated EHR and Practice Management system that allows for smooth transitioning between patient records and administrative tasks such as telehealth capabilities, facilitating convenient virtual patient consultations.

NextGen also supports integrations with a wide array of diagnostic equipment and medical devices, ensuring a seamless flow of patient data. Additionally, the software integrates with most major pharmacies, allowing for swift prescription management.


From $299/user/month (billed annually).


  • Enhances practice efficiency with a seamless interface
  • Fully integrated EHR and Practice Management system
  • Extensive integration capabilities with diagnostic equipment and pharmacies


  • Pricing may be high for smaller practices
  • Reporting features could be more flexible
  • Some users report minor software glitches

4. Greenway Health - Best for revenue cycle management and billing solutions

Greenway Health enterprise medical software interface
Here's Greenway Health's practice management feature.

Greenway Health is a robust software solution that specializes in streamlining revenue cycle management and improving billing processes in healthcare. The system is also equipped to make financial operations smoother and more effective for health enterprises.

Why I Picked Greenway Health:

I chose Greenway Health because of its impressive approach to managing profitability, revenue cycles, and billing operations. The software's expertise in these areas helps healthcare providers optimize their financial operations as well as ensuring a smooth flow of revenue and reducing billing errors. This distinct specialization makes Greenway Health the best tool for revenue cycle management and billing solutions.

Standout features & integrations:

Greenway Health excels with features such as integrated medical EHR, practice management software, and interoperability services, complementing its strong revenue cycle management capabilities. Its Interoperability Clearinghouse feature also enables the exchange of health data across different healthcare systems.

Additionally, Greenway Health provides a unified system that communicates effectively with pharmacies, labs, and radiology centers, ensuring an efficient flow of medical data.


From $199/user/month (min 5 seats).


  • Specialized in revenue cycle management and billing solutions
  • Offers a unified system with strong integrations
  • Provides an Interoperability Clearinghouse for data exchange


  • Minimum of 5 seats required for purchasing
  • Some users report a steep learning curve
  • User interface could be more intuitive
Compulink enterprise medical software interface
Here's the EHR management feature in Compulink.

Compulink is a versatile enterprise medical software solution designed with an array of customizable features to support multi-specialty medical practices. The software's flexibility also allows it to adapt to various operational needs, making it a valuable tool for healthcare providers with diverse specialties.

Why I Picked Compulink:

Compulink caught my attention due to its high level of customization that caters to multi-specialty practices. This versatility gives the software a unique advantage; it can mold itself according to the unique needs of each specialty within a healthcare institution. Therefore, in my opinion, Compulink is the best choice for multi-specialty practices seeking a customizable platform.

Standout features & integrations:

Some of Compulink's most compelling features such as customizable EHR templates, practice management tools, and patient engagement options contributes to its versatility, enabling the software to adapt to a variety of medical specialties.

In terms of integrations, Compulink can interface with labs, pharmacies, hospitals, and radiology facilities. It also provides a billing service integration that supports efficient revenue management.


From $349/user/month (billed annually).


  • Highly customizable to accommodate various specialties
  • Includes a wide array of features for comprehensive management
  • Allows integration with several external services


  • Pricing is on the higher end
  • Annual billing could be inconvenient for some practices
  • Some users may find the customization process complex

6. PracticeFusion - Best for small to mid-size practices requiring a cloud-based EHR

PracticeFusion enterprise medical software interface
Here's the charting feature in PracticeFusion, which show the patients' vitals and diagnosis record.

PracticeFusion is an electronic health record (EHR) system designed to provide cloud-based health record services for small to mid-size medical practices. Its easily accessible, intuitive, and scalable solution is also known to streamline workflow and increase the efficiency of the practices.

Why I Picked PracticeFusion:

I included PracticeFusion in this list for its robust cloud-based EHR services, tailor-made for smaller and mid-sized practices. It has the distinct advantages such as being easily accessible from any location, a critical attribute for practices that require flexibility and based on these factors, I believe PracticeFusion stands out as the best choice for small to mid-size practices seeking a cloud-based EHR.

Standout features & integrations:

PracticeFusion's features such as appointment scheduling, clinical charting, and e-prescribing stand out, making it easier for healthcare professionals to manage their workflow. It also includes telehealth functionality, a vital need in modern healthcare.

PracticeFusion also integrates seamlessly with labs, pharmacies, imaging centers, and billing systems, which contributes to its efficient functionality. It also integrates with billing software, further simplifying financial processes for practices.


From $149/user/month.


  • Cloud-based accessibility from any location
  • Comprehensive integration options with other healthcare systems
  • Includes telehealth functionality


  • Pricing may not be feasible for very small practices
  • The interface might require a learning curve for some users
  • Lacks extensive customization options

7. Epic - Best for large healthcare organizations prioritizing patient care coordination

Epic patient summary screenshot
Here's Epic patient summary screenshot

Epic is a comprehensive healthcare software solution that offers a broad range of applications to manage the clinical, access, and revenue functions of healthcare organizations. Given its wide-ranging capabilities and advanced features, it's also well-suited for large healthcare institutions that emphasize patient care coordination.

Why I Picked Epic:

I selected Epic for its comprehensive ability to handle diverse healthcare functions and its emphasis on patient care coordination. Also, its’ sophisticated architecture and a broad range of features enable it to address the intricate requirements of large healthcare organizations effectively. I find Epic best for such organizations due to its proven track record in enhancing patient care coordination.

Standout features & integrations:

Epic's standout features include an EMR system, patient scheduling, registration, and billing applications. It also offers features like MyChart, which provides patients with personal and family health information.

Additionally, Epic provides integrations with numerous third-party systems, including labs, pharmacies, and medical imaging centers, enhancing the tool's reach and functionality. It also integrates well with other healthcare IT systems using standard health data exchange protocols.


Pricing upon request


  • Comprehensive range of features to manage various healthcare functions
  • Strong emphasis on patient care coordination
  • Robust integrations with third-party healthcare systems


  • Requires significant initial investment and setup
  • Can be complex to navigate for new users
  • The implementation process can be lengthy

8. PrognoCIS - Best for streamlined scheduling and easy e-prescribing

PrognoCIS enterprise medical software interface
Here's the customizable EHR feature in PrognoCIS.

PrognoCIS is a versatile electronic health record (EHR) platform that specializes in efficient scheduling and effortless e-prescribing. These particular strengths make it an excellent choice for healthcare practices looking to enhance their scheduling capabilities and simplify their e-prescribing processes.

Why I Picked PrognoCIS:

I chose PrognoCIS based on its impressive scheduling and e-prescribing capabilities. Its scheduling features are advanced and intuitive, while the e-prescribing module simplifies the prescription process, reducing errors and saving time. Therefore, I believe PrognoCIS is the best tool for practices seeking to streamline these specific areas.

Standout features & integrations:

PrognoCIS offers an array of useful features, including patient portal access, customizable EHR templates, and telemedicine capabilities. Of course, its standout features remain the intuitive scheduling and efficient e-prescribing modules.

When it comes to integrations, PrognoCIS supports a wide range of healthcare IT systems, making it easy to exchange data with labs, pharmacies, and other healthcare providers. Additionally, it can interface with medical billing systems and medical devices for comprehensive care delivery.


From $200/user/month


  • Robust scheduling and e-prescribing capabilities
  • Customizable EHR templates
  • Strong integrations with healthcare IT systems


  • A high starting price may not be affordable for smaller practices
  • The user interface may be less intuitive compared to other EHRs
  • Requires training to effectively use advanced features

9. AdvancedMD - Best for practices desiring an all-in-one medical management solution

AdvancedMD enterprise medical software interface
Here's the AdvancedMD dashboard feature.

AdvancedMD is a unified suite of software solutions designed for mental health, physical therapy, medical healthcare organizations, and independent physician practices. It has been made to handle everything from appointment scheduling and medical billing to clinical workflow management and reporting. This extensive feature set makes it an ideal choice for practices that desire a holistic approach to medical management.

Why I Picked AdvancedMD:

When making my selection, I looked at AdvancedMD's broad range of integrated tools. Its all-encompassing nature makes it stand apart from other EHR systems. It manages to bundle various aspects of healthcare practice management into a single platform, which is why I think it's best for practices seeking an all-in-one solution.

Standout features & integrations:

AdvancedMD offers features such as customizable EHR templates, practice management, telemedicine capabilities, eligibility checks, patient experience optimization, and a business intelligence reporting tool. It excels at providing a holistic approach to medical management.

In terms of integrations, AdvancedMD provides seamless data sharing with labs, pharmacies, and other EHR systems. It also supports integration with revenue cycle management systems, which can help streamline the financial aspects of practice.


Starting from $429/user/month


  • Comprehensive suite of tools for medical management
  • Customizable EHR templates and reporting capabilities
  • Integrates well with other healthcare and financial systems


  • High starting price point may be a barrier for smaller practices
  • The complexity of features may require a learning curve
  • Some users may find the interface less intuitive compared to other systems

10. Kareo - Best for independent practices seeking a user-friendly interface

Kareo enterprise medical software interface
Here's Kareo's billing analytics feature.

Kareo is an efficient EHR system designed to simplify healthcare management. It offers a variety of tools for medical billing, patient engagement, and telehealth, all wrapped in a user-friendly interface. Its ease of use makes it particularly suitable for independent practices that need a straightforward, easy-to-navigate EHR solution.

Why I Picked Kareo:

In selecting Kareo for this list, I valued its dedication to a simple, easy-to-understand interface without sacrificing functionality. This user-friendliness sets it apart from many EHR solutions in the market. Its commitment to simplicity also makes it the best fit for independent practices that prefer an easy-to-navigate system.

Standout features & integrations:

Kareo includes notable features such as appointment reminders, secure messaging, a patient portal, and integrated in-house credit card processing. Furthermore, its billing features are robust and can help streamline financial operations within a practice.

As for integrations, Kareo supports interfacing with labs, pharmacies, and other healthcare systems. Moreover, it integrates with popular calendar apps, ensuring seamless scheduling experiences.


Starting from $160/user/month


  • User-friendly interface makes it easy to navigate
  • Comprehensive medical billing software and patient engagement tools
  • Strong integration with labs, pharmacies, and calendar apps


  • It might lack some advanced features found in more complex systems
  • Some users have reported customer service could be improved
  • Learning curve may be present for individuals new to EHR systems

11. PureOHS - Best for occupational health and safety management

PureOHS enterprise medical software interface
Screenshot of PureOHS dashboard.

PureOHS is a comprehensive solution dedicated to managing occupational health and safety data. It's also an intuitive software that aids organizations in managing medical surveillance, clinical data, and employee health records. This focus on occupational health and safety is what makes it ideal for organizations prioritizing these aspects.

Why I Picked PureOHS:

I picked PureOHS because of its singular focus on occupational health and safety management. This niche specialization allows PureOHS to offer features and functionalities that stand out from general EHR systems. I determined it to be best for use cases that prioritize occupational health due to its in-depth management of medical surveillance, clinical data, and employee health records.

Standout features & integrations:

PureOHS's standout features include powerful tools for risk assessment, compliance tracking, and electronic medical records management. It also provides detailed reporting capabilities, offering deep insights into the health and safety landscape of an organization.

PureOHS integrates with various other systems, including HR and Payroll platforms, which makes it easier for businesses to consolidate data and streamline processes.


Pricing upon request


  • Specialized in occupational health and safety
  • Extensive features for risk assessment and compliance tracking
  • Integration capabilities with HR and payroll platforms


  • Pricing isn't transparent and requires request
  • Could be too specialized for organizations needing a more general EHR software
  • User interface might feel outdated compared to some modern EHR platforms

12. AthenaHealth - Best for improved revenue capture and claim management

AthenaHealth enterprise medical software interface
Here's the patient management feature in AthenaHealth.

AthenaHealth is a cloud-based EMR software provider that helps medical organizations manage patient care and streamline administrative tasks. With its robust revenue cycle management capabilities, AthenaHealth stands out for practices that seek improved revenue capture and claim management.

Why I Picked AthenaHealth:

In selecting AthenaHealth, I was drawn to its well-developed revenue cycle management tools that address the critical financial aspects of running a healthcare practice. The system stands out with its proactive claim management, aiming to reduce claim errors and increase successful reimbursements. It was also named 2022 Best in KLAS for both small practice Ambulatory EMR and Practice Management (PM) in the US. Therefore, I believe AthenaHealth is best for use cases that prioritize revenue capture and claim management.

Standout features & integrations:

Key features of AthenaHealth include an integrated practice management solution, patient engagement tools, and, most importantly, its comprehensive revenue cycle management (RCM). These features are especially useful for practices focused on improving their financial performance.

AthenaHealth integrates seamlessly with various other software solutions, such as labs, pharmacies, hospitals, and health systems, for a holistic patient care approach.


Pricing upon request


  • Robust revenue cycle management tools
  • Seamless integration with various software solutions
  • Cloud-based software ensures easy accessibility


  • Pricing information isn't readily available
  • Some users may find the interface complex
  • Implementing system-wide changes can be challenging

Other Enterprise Medical Software

Below is a list of additional enterprise medical software that I shortlisted, but did not make it to the top 12. Definitely worth checking them out.

  1. Centricity Practice Solutions - Good for comprehensive practice management
  2. Enterprise Health - Good for occupational health and compliance management
  3. Medbase - Good for cloud-based healthcare management
  4. HealthStream - Good for clinical development and learning management
  5. Stryker - Good for surgical and patient handling solutions

Selection Criteria for Enterprise Medical Software

In the journey of selecting the right enterprise medical software, I've evaluated dozens of tools and drilled down to a few that offer standout value in functionality, feature set, and usability. With my medical and technological expertise, I tested each of these tools considering their core functionality, key features, and ease of use.

Core Functionality:

Enterprise medical software should enable users to:

  • Manage patient records efficiently
  • Schedule and track appointments
  • Facilitate billing and claim management
  • Incorporate telehealth services for remote consultations
  • Generate insightful reports for decision-making

Key Features:

When examining these software options, I focused on these key features:

  • Interoperability: Seamless communication with other health systems, labs, pharmacies, and EHRs
  • Compliance: Adherence to privacy and security standards, such as HIPAA-compliant
  • Customization: Ability to adapt the software to specific workflows and practice needs
  • Mobile Access: Enabling medical staff to access patient data and perform key tasks via a mobile app
  • Patient Portal: A secure online portal that allows patients to schedule appointments, view their medical records, and communicate with their healthcare providers


For enterprise medical software, the user experience is critical, focusing on:

  • Intuitive Interface: The software needs a design that's easy to navigate, reducing the learning curve for staff
  • Onboarding and Support: A robust training program to get users up and running, coupled with responsive customer support for resolving issues
  • System Performance: Smooth, lag-free operation, ensuring tasks can be performed quickly and efficiently
  • Scalability: The software should be able to accommodate growth, handling more patients and more complex workflows as a practice expands.

Most Common Questions Regarding Enterprise Medical Software

What are the benefits of using enterprise medical software?

Using enterprise medical software brings several advantages to healthcare organizations. These benefits include:

  1. Efficiency: These tools streamline operations, and automate repetitive tasks such as appointment scheduling and billing.
  2. Comprehensive Patient Care: They facilitate a more holistic view of patient health by integrating various sources of health information.
  3. Improved Decision Making: The software provides useful data analysis and real-time reporting, aiding healthcare professionals in making informed decisions.
  4. Enhanced Patient Engagement: Many of these tools offer patient portals that empower patients to take an active role in their healthcare.
  5. Regulatory Compliance: They help in ensuring that healthcare providers comply with various regulations and standards.

How much do these tools typically cost?

The pricing for enterprise medical software can vary widely depending on the size of the healthcare organization, the number of users, and the complexity of the required functionality. The price usually falls in a monthly or annual subscription model.

What are the typical pricing models for these tools?

Many enterprise medical software providers offer subscription-based pricing, typically charged per user per month. Some offer a tiered pricing model, with different tiers providing varying levels of features and functionality. A few may also have a one-time licensing fee model, though this is less common.

What is the typical range of pricing?

The pricing can range anywhere from $20/user/month to over $500/user/month like Carecloud, depending on the functionality and scale of the software. For instance, AthenaHealth and Athenaone start at $140/user/month, while Kareo begins at $160/user/month.

Which are the cheapest and most expensive software?

Kareo, with a starting price of $160/user/month, tends to be one of the more affordable options for enterprise medical software. On the other end of the spectrum, AthenaHealth, with plans starting at $140/user/month, can be among the more costly solutions.

Are there any free tool options available?

While free versions of enterprise medical software are not common, some providers may offer a limited feature set for free or a free trial period for users such as DrChrono to test out the software before committing to a purchase. However, for comprehensive features and functionality, a paid plan is usually necessary.

More Enterprise Medical Software Reviews


In summary, selecting the right enterprise medical software is a strategic decision that can greatly impact a healthcare organization's efficiency, patient care, and decision-making capabilities. The wide variety of tools available, each with its unique features and selling points, necessitates a careful review of your organization's specific needs.

Key Takeaway 1: Understand your use case - Different tools excel in various areas such as revenue capture, occupational health management, or user-friendly interfaces. Be clear on what your organization's needs are and choose a tool that best aligns with those needs.

Key Takeaway 2: Consider usability and integration - Ease of use can greatly influence adoption rates within your organization. Also, consider how well the software integrates with other tools your organization is already using or plans to use.

Key Takeaway 3: Keep in mind the pricing model - The pricing structure of these tools can vary significantly. Understand the different pricing models, and choose a tool that fits within your budget without compromising on the features that are most important to your organization.

What do you think?

While I've tried to cover some of the best enterprise medical software options available, there might be others that I may have overlooked. If you've had a great experience with a tool not listed here, please don't hesitate to share it in the comments. Your suggestions and feedback will help enrich this guide for others seeking the best software solutions for their healthcare organizations.

By John Payne

John Payne is the co-founder and company director of Symphony Health. With over 20 years of management experience John is working alongside his wife, Dr. Kate Payne to build a multi-site Medical Practice where staff work collaboratively for the good of their patients. John is passionate about improving access to quality Healthcare in North Vancouver and sharing best practice with other people managing medical practices.